Raw Lion's Mane, also known as the Yamabushitake mushroom

Best Lion’s Mane Mushroom Supplements

Our list of the top rated lion's mane mushroom supplements online for anyone in search of the best.

We've reviewed several online lion's mane supplement brands to date, 44 if you're counting, many of which are cheap knock offs from china. In this list, we took the time to boil it all down to which products we think are most deserving of your attention. After all, you can only choose one—and presumably, you want the best experience. We've made sure to include something for everyone, including those mushroom drink mix things you keep seeing around.

After 44 products reviewed since 2015, we think the uber-clean, no-filler Host Defense Lion’s Mane Mushroom Capsules are the best lion’s mane supplement brand for most people. At a practical price, it delivers high-quality lion’s mane mushroom in a vegetable based capsule.

possible side effects of lion's mane
possible side effects of lion's mane

1. Host Defense Lion’s Mane

Our pick - what we would take
Host Defense makes an excellent lion’s mane (hericium erinaceus) product that comes from certified organic mushrooms that are grown right here in the USA. It’s also freeze-dried to help preserve the freshness and effectiveness of the lions mane mushroom.
Best Lion's Mane Capsules
Best Lion's Mane Capsules
Our Rating
Overall Rating 100%
Ingredients 100%
Effectiveness 100%
Quality 100%


The Details
Serving Size 2 Capsules
Lion's mane content 1000 mg
Organic Yes

No need to fear additives or fillers with these lions mane capsules. Vegetable based capsules that contain only freeze-dried myceliated brown rice and pullulan. No gelatin or added preservatives.

This supplement scored a perfect rating in our review, each serving containing 1000 mg of lions mane per serving. These all add up to make Host Defense Lion’s Mane a superior choice for a daily-use supplement.

PS: YES! This is the brand that is featured on Joe Rogan Experience with Paul Stamets (The man behind the brand of Host defense)

2. Ancient Apothecary Fermented Lion's Mane


Ancient Apothecary is a brand made by the infamous Dr. Axe from draxe.com. This Fermented Lion’s Mane is made with an excellent, all-natural blend of herbs including ashwagandha, apple cider vinegar, ginger, and tumeric, mushrooms, and essential oils. This will surely appeal to customers looking for a supplement containing a blend of the latest top health herbs the world is talking about.

Based around providing you with 1,525 mg of fermented lions mane, Ancient Apothecary Fermented Lion’s Mane combines a slew of other plants, herbs, and essential oils to create a powerful daily supplement. To top it all off, its made using only organic ingredients. 

We have reviewed and ranked this product with a fairly high overall rating. There isn’t much terribly wrong with it, aside from being slightly more expensive, using a plastic container (which dr.axe should know is something top health practitioners hate), and having too many other herbs in its formula.  This isn’t bad, unless you are looking for just lions mane supplement, without all the other extras. 


3. Oregon's Wild Harvest Lion's Mane Plus


Oregon’s Wild Harvest is the lions mane brand of choice for people who really appreciate organic ingredients with no additives inside the capsules. Its called Lion’s Mane Plus because it contains ginkgo leaf and small amounts of B-Vitamins.

Their formula is powerful however, the capsules are made from bovine gelatin, which means vegetarians or vegans will have to look else where for a product. Aside from that, the formula is very clean, containing a little bit of holy basil, lemon, and guava and nothing else. This should be the go-to option for people who want a trusted, safe, and effective lions mane.


4. Solaray Organically Grown Fermented Lion’s Mane

Solaray Organically Grown Fermented Lion's Mane

Solaray Organically Grown Fermented Lion’s Mane is one of the best fermented lions mane products that is also fully organic on the market. Solaray combines quality, effectiveness, and a solid ingredient profile thanks to its ultra clean formula. 

Its relatively affordable when compared to other organic brands on the market, though the organic whole oat biomass used to help grow this lions mane mushroom is not liked by our customers. However, it can be a challenge to find a lions mane product with a clean ingredient profile like this brand.


5. Om Organic Mushroom Nutrition Lion's Mane

OM Mushroom Nutrition's 30 capsule container

Om Organic Mushroom Nutrition is one of the biggest producers of mushroom powders in the USA market. These capsules are new to this brands collection, as they have been focused solely on producing high quality bulk powders.

Like some other supplements that focus on quality, Om Organic Mushroom Nutrition Lion’s Mane is made with 100% organic lions mane grown right here in the USA. Each serving contains 2,000 mg of lions mane packed into a vegetable based capsule. This brand is one of the few brands that you can actually find in retail stores.

During our review process, this product did not have many things wrong with it. The only things we noted were that the lions mane mushroom used in this supplement is grown on organic whole oats, which some top mushroom supplement connoisseurs dislike and the plastic container can be off-putting to some customers. 



There has been only a few solid research studies on Lion's Mane mushroom (Yamabushitake). The research that is out though seems to be promising for a number of potential benefits.
Yes. There are multiple products on the market that are sold as sleepy time formulas that include Lion's Mane. Customers do report more intense dreams which can lead to restlessness. The majority of lion's mane supplements are sold often as focus improving and often instruct customers to take it during the day.
Yes. You can often find the raw lion's mane mushroom at your local Whole Foods store next to the other mushrooms, often packaged on its own. There is nothing in lion's mane mushroom that would make it illegal.
Aside from the standard ‎Vitamin B-12, ‎Omega-3 fatty acids, ‎Iron, ‎and Calcium, lion's mane supplements can help expand your diet by adding healthy mushrooms into your everyday life. The high anti-oxidant properties are nice too.
Lion's mane extract is often on the top of the list for most nootropic products when it comes to focus. The research is still limited but the alleged effects on Nerve Growth Factor (NGF) seem to interest customers.
Yes. They can be. Make sure your supplement brand doesn't have gelatin as it's capsule base. Most products we reviewed used gelatin. The top ranking brands used plant based capsules.
For most customers it's to diversify the amount of healthy mushrooms into the diet. Lion's mane itself is said to hold many anti-oxidant properties. Often customers like to rotate between the types of high quality mushroom products (reishi, turkey tail, cordyceps).
The brand that Paul and Joe Rogan talk about is called Host Defense® Mushrooms.
The best place to buy lion mane mushroom depends on what you are looking for. If you want the raw mushroom your best chance is at a health food store or Whole Foods Market, or Earth Fare, Or Publix. GNC and The Vitamin Shoppe are good retail stores to check out. Online is always a good option for most of the supplements, Amazon is the best place to start.