Best Lion’s Mane Mushroom Supplements

Our list of the top rated lion's mane mushroom supplements online for anyone in search of the best.

We've reviewed several online lion's mane supplement brands to date, 44 if you're counting, many of which are cheap knock offs from china. In this list, we took the time to boil it all down to which products we think are most deserving of your attention. After all, you can only choose one—and presumably, you want the best experience. We've made sure to include something for everyone, including those mushroom drink mix things you keep seeing around.

After 44 products reviewed since 2015, we think the uber-clean, no-filler Host Defense Lion’s Mane Mushroom Capsules are the best lion’s mane supplement brand for most people. At a practical price, it delivers high-quality lion’s mane mushroom in a vegetable based capsule.

1. Host Defense Lion’s Mane

Our pick - what we would take
Host Defense makes an excellent lion’s mane (hericium erinaceus) product that comes from certified organic mushrooms that are grown right here in the USA. It’s also freeze-dried to help preserve the freshness and effectiveness of the lions mane mushroom.
Host Defense Lion's Mane Capsules
Best Lion's Mane Capsules
Our Rating
Overall Rating 100%
Ingredients 100%
Effectiveness 100%
Quality 100%


  • USA Grown Lion's Mane (Hericium erinaceus) mycelium
  • Organic and Vegan Safe
  • 1000 mg Lion's Mane Per Serving
- Will Sell Out Quickly -
The Details
Serving Size 2 Capsules
Lion's mane content 1000 mg
Organic Yes

No need to fear additives or fillers with these lions mane capsules. Vegetable based capsules that contain only freeze-dried myceliated brown rice and pullulan. No gelatin or added preservatives.

This supplement scored a perfect rating in our review, each serving containing 1000 mg of lions mane per serving. These all add up to make Host Defense Lion’s Mane a superior choice for a daily-use supplement.

PS: YES! This is the brand that is featured on Joe Rogan Experience with Paul Stamets (The man behind the brand of Host defense)

2. Ancient Apothecary Fermented Lion's Mane


Ancient Apothecary is a brand made by the infamous Dr. Axe from This Fermented Lion’s Mane is made with an excellent, all-natural blend of herbs including ashwagandha, apple cider vinegar, ginger, and tumeric, mushrooms, and essential oils. This will surely appeal to customers looking for a supplement containing a blend of the latest top health herbs the world is talking about.

Based around providing you with 1,525 mg of fermented lions mane, Ancient Apothecary Fermented Lion’s Mane combines a slew of other plants, herbs, and essential oils to create a powerful daily supplement. To top it all off, its made using only organic ingredients. 

We have reviewed and ranked this product with a fairly high overall rating. There isn’t much terribly wrong with it, aside from being slightly more expensive, using a plastic container (which dr.axe should know is something top health practitioners hate), and having too many other herbs in its formula.  This isn’t bad, unless you are looking for just lions mane supplement, without all the other extras. 

  • 1525 mg Organic Full Spectrum Lion's Mane
  • Gluten-Free
  • non-GMO
  • Vegetarian + Vegan
  • Contains Essential Oils
  • Brand by Dr. Axe
  • Plastic Container
  • Contains other herbs
  • Can be expensive

3. Oregon's Wild Harvest Lion's Mane Plus


Oregon’s Wild Harvest is the lions mane brand of choice for people who really appreciate organic ingredients with no additives inside the capsules. Its called Lion’s Mane Plus because it contains ginkgo leaf and small amounts of B-Vitamins.

Their formula is powerful however, the capsules are made from bovine gelatin, which means vegetarians or vegans will have to look else where for a product. Aside from that, the formula is very clean, containing a little bit of holy basil, lemon, and guava and nothing else. This should be the go-to option for people who want a trusted, safe, and effective lions mane.

  • Certified Organic Lion's Mane
  • No Filler Ingredients or Additives
  • Verified Non-GMO by SGS
  • Glass Container
  • Bovine Gelatin Capsules
  • Non-vegetarian

4. Solaray Organically Grown Fermented Lion’s Mane


Solaray Organically Grown Fermented Lion’s Mane is one of the best fermented lions mane products that is also fully organic on the market. Solaray combines quality, effectiveness, and a solid ingredient profile thanks to its ultra clean formula. 

Its relatively affordable when compared to other organic brands on the market, though the organic whole oat biomass used to help grow this lions mane mushroom is not liked by our customers. However, it can be a challenge to find a lions mane product with a clean ingredient profile like this brand.

  • 1,000 mg of Organic Fermented Lion's Mane per serving
  • Clean ingredient profile
  • No fillers or additives
  • Trusted Brand
  • Vegetable cellulose capsules
  • Plastic container
  • Whole Oat Biomass

5. Om Organic Mushroom Nutrition Lion's Mane

OM Mushroom Nutrition's 30 capsule container

Om Organic Mushroom Nutrition is one of the biggest producers of mushroom powders in the USA market. These capsules are new to this brands collection, as they have been focused solely on producing high quality bulk powders.

Like some other supplements that focus on quality, Om Organic Mushroom Nutrition Lion’s Mane is made with 100% organic lions mane grown right here in the USA. Each serving contains 2,000 mg of lions mane packed into a vegetable based capsule. This brand is one of the few brands that you can actually find in retail stores.

During our review process, this product did not have many things wrong with it. The only things we noted were that the lions mane mushroom used in this supplement is grown on organic whole oats, which some top mushroom supplement connoisseurs dislike and the plastic container can be off-putting to some customers. 

  • 2,000 mg of 100% Organic Lion's Mane per serving
  • Vegetable cellulose capsules
  • No extra ingredients or additives
  • Well known brand
  • Grown in USA
  • Plastic container
  • Organic whole oats
Lion’s Mane Mushroom Summary
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